2OW9

Crystal structure analysis of the MMP13 catalytic domain in complex with specific inhibitor

2OW9 の概要

• エントリーDOI: 10.2210/pdb2ow9/pdb
• 分子名称: Collagenase 3, ZINC ION, CALCIUM ION, ... (7 entities in total)
• 機能のキーワード: complex crystal structure, martix metalloproteinase, mmp13, specific mmp13 inhibitor, s1' mmp13 inhibitor, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix : P45452
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39711.86

構造登録者

Pavlovsky, A.G. (登録日: 2007-02-15, 公開日: 2007-02-27, 最終更新日: 2023-08-30)

• 主引用文献: Johnson, A.R.,Pavlovsky, A.G.,Ortwine, D.F.,Prior, F.,Man, C.F.,Bornemeier, D.A.,Banotai, C.A.,Mueller, W.T.,McConnell, P.,Yan, C.,Baragi, V.,Lesch, C.,Roark, W.H.,Wilson, M.,Datta, K.,Guzman, R.,Han, H.K.,Dyer, R.D.; Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.; J.Biol.Chem., 282:27781-27791, 2007; PubMed: 17623656; DOI: 10.1074/jbc.M703286200

実験手法

X-RAY DIFFRACTION (1.74 Å)