2OSS

Crystal structure of the Bromo domain 1 in human Bromodomain Containing Protein 4 (BRD4)

2OSS の概要

• エントリーDOI: 10.2210/pdb2oss/pdb
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL (3 entities in total)
• 機能のキーワード: brd4, bromodomain containing protein 4, structural genomics consortium, sgc, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15285.58

構造登録者

Filippakopoulos, P.,Keates, T.,Savitsky, P.,Burgess, N.,Pike, A.C.W.,Ugochukwu, E.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Sundstrom, M.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2007-02-06, 公開日: 2007-02-20, 最終更新日: 2023-08-30)

• 主引用文献: Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S.; Histone recognition and large-scale structural analysis of the human bromodomain family.; Cell(Cambridge,Mass.), 149:214-231, 2012; PubMed: 22464331; DOI: 10.1016/j.cell.2012.02.013

実験手法

X-RAY DIFFRACTION (1.35 Å)