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2OQI

Human Dipeptidyl Peptidase IV (DPP4) with Piperidinone-constrained phenethylamine

2OQI の概要
エントリーDOI10.2210/pdb2oqi/pdb
分子名称Dipeptidyl peptidase 4 (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (Adenosine deaminase complexing protein 2) (ADABP), (4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONE (2 entities in total)
機能のキーワードserine-peptidase, inhibitor, hydrolase
由来する生物種Homo sapiens (human)
細胞内の位置Dipeptidyl peptidase 4 soluble form: Secreted . Cell membrane ; Single- pass type II membrane protein: P27487
タンパク質・核酸の鎖数4
化学式量合計338242.84
構造登録者
主引用文献Pei, Z.,Li, X.,Geldern, T.W.,Longenecker, K.,Pireh, D.,Stewart, K.D.,Backes, B.J.,Lai, C.,Lubben, T.H.,Ballaron, S.J.,Beno, D.W.,Kempf-Grote, A.J.,Sham, H.L.,Trevillyan, J.M.
Discovery and Structure-Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors.
J.Med.Chem., 50:1983-1987, 2007
Cited by
PubMed: 17367123
DOI: 10.1021/jm061436d
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.8 Å)
構造検証レポート
Validation report summary of 2oqi
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-09-18に公開中

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