2ON7

Structure of NaGST-1

2ON7 の概要

• エントリーDOI: 10.2210/pdb2on7/pdb
• 関連するPDBエントリー: 1TW9 2ON5
• 分子名称: Na Glutathione S-transferase 1 (2 entities in total)
• 機能のキーワード: gst; hookworm; necator, transferase
• 由来する生物種: Necator americanus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 94841.44

構造登録者

Asojo, O.A.,Ngamelue, M.,Homma, H.,Goud, G.,Zhan, B.,Hotez, P.J. (登録日: 2007-01-23, 公開日: 2007-08-07, 最終更新日: 2024-10-30)

主引用文献

Asojo, O.A.,Homma, K.,Sedlacek, M.,Ngamelue, M.,Goud, G.N.,Zhan, B.,Deumic, V.,Asojo, O.,Hotez, P.J.
X-ray structures of Na-GST-1 and Na-GST-2 two glutathione s-transferase from the human hookworm Necator americanus
Bmc Struct.Biol., 7:42-42, 2007

PubMed Abstract: Human hookworm infection is a major cause of anemia and malnutrition of adults and children in the developing world. As part of on-going efforts to control hookworm infection, The Human Hookworm Vaccine Initiative has identified candidate vaccine antigens from the infective L3 larval stages and adult stages of the parasite. Adult stage antigens include the cytosolic glutathione-S-transferases (GSTs). Nematode GSTs facilitate the inactivation and degradation of a variety of electrophilic substrates (drugs) via the nucleophilic addition of reduced glutathione. Parasite GSTs also play significant roles in multi-drug resistance and the modulation of host-immune defense mechanisms.

PubMed: 17594497
DOI: 10.1186/1472-6807-7-42

実験手法

X-RAY DIFFRACTION (2.4 Å)