2OGZ

Crystal structure of DPP-IV complexed with Lilly aryl ketone inhibitor

Summary for 2OGZ

Entry DOI	10.2210/pdb2ogz/pdb
Descriptor	Dipeptidyl peptidase, 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE (3 entities in total)
Functional Keywords	dipeptidyl peptidase iv, cd26, dpiv, dpp-iv, dpp4, serine protease, inhibitor, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Dipeptidyl peptidase 4 soluble form: Secreted . Cell membrane ; Single- pass type II membrane protein: P27487
Total number of polymer chains	2
Total formula weight	169582.00
Authors	Timm, D.E. (deposition date: 2007-01-09, release date: 2007-03-06, Last modification date: 2023-08-30)
Primary citation	Sheehan, S.M.,Mest, H.J.,Watson, B.M.,Klimkowski, V.J.,Timm, D.E.,Cauvin, A.,Parsons, S.H.,Shi, Q.,Canada, E.J.,Wiley, M.R.,Ruehter, G.,Evers, B.,Petersen, S.,Blaszczak, L.C.,Pulley, S.R.,Margolis, B.J.,Wishart, G.N.,Renson, B.,Hankotius, D.,Mohr, M.,Zechel, J.C.,Michael Kalbfleisch, J.,Dingess-Hammond, E.A.,Boelke, A.,Weichert, A.G. Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site. Bioorg.Med.Chem.Lett., 17:1765-1768, 2007 Cited by PubMed: 17239592 DOI: 10.1016/j.bmcl.2006.12.074 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation