2OGZ

Crystal structure of DPP-IV complexed with Lilly aryl ketone inhibitor

2OGZ の概要

• エントリーDOI: 10.2210/pdb2ogz/pdb
• 分子名称: Dipeptidyl peptidase, 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE (3 entities in total)
• 機能のキーワード: dipeptidyl peptidase iv, cd26, dpiv, dpp-iv, dpp4, serine protease, inhibitor, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Dipeptidyl peptidase 4 soluble form: Secreted . Cell membrane ; Single- pass type II membrane protein: P27487
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 169582.00

構造登録者

Timm, D.E. (登録日: 2007-01-09, 公開日: 2007-03-06, 最終更新日: 2023-08-30)

• 主引用文献: Sheehan, S.M.,Mest, H.J.,Watson, B.M.,Klimkowski, V.J.,Timm, D.E.,Cauvin, A.,Parsons, S.H.,Shi, Q.,Canada, E.J.,Wiley, M.R.,Ruehter, G.,Evers, B.,Petersen, S.,Blaszczak, L.C.,Pulley, S.R.,Margolis, B.J.,Wishart, G.N.,Renson, B.,Hankotius, D.,Mohr, M.,Zechel, J.C.,Michael Kalbfleisch, J.,Dingess-Hammond, E.A.,Boelke, A.,Weichert, A.G.; Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site.; Bioorg.Med.Chem.Lett., 17:1765-1768, 2007; PubMed: 17239592; DOI: 10.1016/j.bmcl.2006.12.074

実験手法

X-RAY DIFFRACTION (2.1 Å)