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2OAG

Crystal structure of human dipeptidyl peptidase IV (DPPIV) with pyrrolidine-constrained phenethylamine 29g

2OAG の概要
エントリーDOI10.2210/pdb2oag/pdb
分子名称Dipeptidyl peptidase 4, (3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE (3 entities in total)
機能のキーワードserine-peptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
由来する生物種Homo sapiens (human)
細胞内の位置Dipeptidyl peptidase 4 soluble form: Secreted . Cell membrane ; Single- pass type II membrane protein: P27487
タンパク質・核酸の鎖数4
化学式量合計337457.80
構造登録者
Backes, B.J.,Longenecker, K.L.,Hamilton, G.L.,Stewart, K.D.,Lai, C.,Kopecka, H. (登録日: 2006-12-15, 公開日: 2007-09-11, 最終更新日: 2023-12-27)
主引用文献Backes, B.J.,Longenecker, K.,Hamilton, G.L.,Stewart, K.,Lai, C.,Kopecka, H.,von Geldern, T.W.,Madar, D.J.,Pei, Z.,Lubben, T.H.,Zinker, B.A.,Tian, Z.,Ballaron, S.J.,Stashko, M.A.,Mika, A.K.,Beno, D.W.,Kempf-Grote, A.J.,Black-Schaefer, C.,Sham, H.L.,Trevillyan, J.M.
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.
Bioorg.Med.Chem.Lett., 17:2005-2012, 2007
Cited by
PubMed: 17276063
DOI: 10.1016/j.bmcl.2007.01.026
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.3 Å)
構造検証レポート
Validation report summary of 2oag
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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