2O4S

Crystal Structure of HIV-1 Protease (Q7K) in Complex with Lopinavir

2O4S の概要

• エントリーDOI: 10.2210/pdb2o4s/pdb
• 分子名称: protease, CHLORIDE ION, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ... (5 entities in total)
• 機能のキーワード: protease, viral protein
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22564.42

構造登録者

Armstrong, A.A.,Muzammil, S.,Jakalian, A.,Bonneau, P.R.,Schmelmer, V.,Freire, E.,Amzel, L.M. (登録日: 2006-12-04, 公開日: 2006-12-12, 最終更新日: 2023-12-27)

• 主引用文献: Muzammil, S.,Armstrong, A.A.,Kang, L.W.,Jakalian, A.,Bonneau, P.R.,Schmelmer, V.,Amzel, L.M.,Freire, E.; Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations.; J.Virol., 81:5144-5154, 2007; PubMed: 17360759; DOI: 10.1128/JVI.02706-06

実験手法

X-RAY DIFFRACTION (1.54 Å)