2O4P
Crystal Structure of HIV-1 Protease (Q7K) in Complex with Tipranavir
Summary for 2O4P
Entry DOI | 10.2210/pdb2o4p/pdb |
Descriptor | protease, N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | protease, viral protein |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22304.37 |
Authors | Kang, L.W.,Armstrong, A.A.,Muzammil, S.,Jakalian, A.,Bonneau, P.R.,Schmelmer, V.,Freire, E.,Amzel, L.M. (deposition date: 2006-12-04, release date: 2006-12-12, Last modification date: 2023-12-27) |
Primary citation | Muzammil, S.,Armstrong, A.A.,Kang, L.W.,Jakalian, A.,Bonneau, P.R.,Schmelmer, V.,Amzel, L.M.,Freire, E. Unique thermodynamic response of tipranavir to human immunodeficiency virus type 1 protease drug resistance mutations. J.Virol., 81:5144-5154, 2007 Cited by PubMed: 17360759DOI: 10.1128/JVI.02706-06 PDB entries with the same primary citation |
Experimental method |
Structure validation
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