2O4H

Human brain aspartoacylase complex with intermediate analog (N-phosphonomethyl-L-aspartate)

Summary for 2O4H

Entry DOI	10.2210/pdb2o4h/pdb
Descriptor	Aspartoacylase, ZINC ION, N-[HYDROXY(METHYL)PHOSPHORYL]-L-ASPARTIC ACID, ... (4 entities in total)
Functional Keywords	canavan disease, n-acetyl-l-aspartate, zinc-dependent hydrolase, aspartoacylase family, hydrolase, aminoacylase-2, acy2, aspa, n-phosphonomethyl-l-aspartate
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P45381
Total number of polymer chains	2
Total formula weight	72121.20
Authors	Le Coq, J.,Pavlovsky, A.,Sanishvili, R.,Viola, R.E. (deposition date: 2006-12-04, release date: 2007-11-06, Last modification date: 2023-08-30)
Primary citation	Le Coq, J.,Pavlovsky, A.,Malik, R.,Sanishvili, R.,Xu, C.,Viola, R.E. Examination of the Mechanism of Human Brain Aspartoacylase through the Binding of an Intermediate Analogue. Biochemistry, 47:3484-3492, 2008 Cited by PubMed: 18293939 DOI: 10.1021/bi702400x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation