2O4H

Human brain aspartoacylase complex with intermediate analog (N-phosphonomethyl-L-aspartate)

2O4H の概要

• エントリーDOI: 10.2210/pdb2o4h/pdb
• 分子名称: Aspartoacylase, ZINC ION, N-[HYDROXY(METHYL)PHOSPHORYL]-L-ASPARTIC ACID, ... (4 entities in total)
• 機能のキーワード: canavan disease, n-acetyl-l-aspartate, zinc-dependent hydrolase, aspartoacylase family, hydrolase, aminoacylase-2, acy2, aspa, n-phosphonomethyl-l-aspartate
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P45381
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72121.20

構造登録者

Le Coq, J.,Pavlovsky, A.,Sanishvili, R.,Viola, R.E. (登録日: 2006-12-04, 公開日: 2007-11-06, 最終更新日: 2023-08-30)

• 主引用文献: Le Coq, J.,Pavlovsky, A.,Malik, R.,Sanishvili, R.,Xu, C.,Viola, R.E.; Examination of the Mechanism of Human Brain Aspartoacylase through the Binding of an Intermediate Analogue.; Biochemistry, 47:3484-3492, 2008; PubMed: 18293939; DOI: 10.1021/bi702400x

実験手法

X-RAY DIFFRACTION (2.7 Å)