2O3V
Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site complexed with paromamine derivative NB33
Summary for 2O3V
Entry DOI | 10.2210/pdb2o3v/pdb |
Related | 2FQN 2G5K 2O3W 2O3X 2O3Y |
Descriptor | RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3'), (2S,3R,4R,5S,6R)-3-AMINO-4-({[(2S,3R,4R,5S,6R)-3-AMINO-2-{[(1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYL]OXY}-5-HYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-4-YL]OXY}METHOXY)-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIOL (3 entities in total) |
Functional Keywords | aminoglycoside, antibiotics, ribosome, decoding site, homo sapiens, eukaryote, cytoplasmic, translation inhibition, stop codon readthrough, rna |
Total number of polymer chains | 2 |
Total formula weight | 15225.34 |
Authors | Kondo, J.,Hainrichson, M.,Nudelman, I.,Shallom-Shezifi, D.,Baasov, T.,Westhof, E. (deposition date: 2006-12-02, release date: 2007-11-06, Last modification date: 2023-12-27) |
Primary citation | Kondo, J.,Hainrichson, M.,Nudelman, I.,Shallom-Shezifi, D.,Barbieri, C.M.,Pilch, D.S.,Westhof, E.,Baasov, T. Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites. Chembiochem, 8:1700-1709, 2007 Cited by PubMed: 17705310DOI: 10.1002/cbic.200700271 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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