2O3V

Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site complexed with paromamine derivative NB33

Summary for 2O3V

• Entry DOI: 10.2210/pdb2o3v/pdb
• Related: 2FQN 2G5K 2O3W 2O3X 2O3Y
• Descriptor: RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3'), (2S,3R,4R,5S,6R)-3-AMINO-4-({[(2S,3R,4R,5S,6R)-3-AMINO-2-{[(1R,2R,3S,4R,6S)-4,6-DIAMINO-2,3-DIHYDROXYCYCLOHEXYL]OXY}-5-HYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-4-YL]OXY}METHOXY)-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIOL (3 entities in total)
• Functional Keywords: aminoglycoside, antibiotics, ribosome, decoding site, homo sapiens, eukaryote, cytoplasmic, translation inhibition, stop codon readthrough, rna
• Total number of polymer chains: 2
• Total formula weight: 15225.34

Authors

Kondo, J.,Hainrichson, M.,Nudelman, I.,Shallom-Shezifi, D.,Baasov, T.,Westhof, E. (deposition date: 2006-12-02, release date: 2007-11-06, Last modification date: 2023-12-27)

• Primary citation: Kondo, J.,Hainrichson, M.,Nudelman, I.,Shallom-Shezifi, D.,Barbieri, C.M.,Pilch, D.S.,Westhof, E.,Baasov, T.; Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites.; Chembiochem, 8:1700-1709, 2007; PubMed: 17705310; DOI: 10.1002/cbic.200700271

Experimental method

X-RAY DIFFRACTION (2.8 Å)