2NZ8
N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1
Summary for 2NZ8
Entry DOI | 10.2210/pdb2nz8/pdb |
Descriptor | ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein (3 entities in total) |
Functional Keywords | trio; rac1; dbl-family gef; rho-family gtpase; dh/ph cassette, signaling protein, cell cycle |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P63000 Cytoplasm : O75962 |
Total number of polymer chains | 2 |
Total formula weight | 56272.72 |
Authors | Chhatriwala, M.K.,Betts, L.,Worthylake, D.K.,Sondek, J. (deposition date: 2006-11-22, release date: 2007-04-10, Last modification date: 2023-08-30) |
Primary citation | Chhatriwala, M.K.,Betts, L.,Worthylake, D.K.,Sondek, J. The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation J.Mol.Biol., 368:1307-1320, 2007 Cited by PubMed: 17391702DOI: 10.1016/j.jmb.2007.02.060 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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