2NZ8

N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1

2NZ8 の概要

• エントリーDOI: 10.2210/pdb2nz8/pdb
• 分子名称: ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein (3 entities in total)
• 機能のキーワード: trio; rac1; dbl-family gef; rho-family gtpase; dh/ph cassette, signaling protein, cell cycle
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane ; Lipid-anchor ; Cytoplasmic side : P63000; Cytoplasm : O75962
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 56272.72

構造登録者

Chhatriwala, M.K.,Betts, L.,Worthylake, D.K.,Sondek, J. (登録日: 2006-11-22, 公開日: 2007-04-10, 最終更新日: 2023-08-30)

• 主引用文献: Chhatriwala, M.K.,Betts, L.,Worthylake, D.K.,Sondek, J.; The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation; J.Mol.Biol., 368:1307-1320, 2007; PubMed: 17391702; DOI: 10.1016/j.jmb.2007.02.060

実験手法

X-RAY DIFFRACTION (2 Å)