2NYY

Crystal structure of botulinum neurotoxin type A complexed with monoclonal antibody CR1

Summary for 2NYY

Related2NZ9
DescriptorBotulinum neurotoxin type A, CR1 monoclonal antibody, ZINC ION, ... (5 entities in total)
Functional Keywordsbotulinum, neurotoxin, fab, protein antibody complex, toxin-immune system complex, toxin/immune system
Biological sourceHomo sapiens (human)
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Cellular locationBotulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted P10845
Total number of polymer chains3
Total molecular weight197535.49
Authors
Stevens, R.C.,Arndt, J.W. (deposition date: 2006-11-21, release date: 2006-12-26, Last modification date: 2016-02-17)
Primary citation
Garcia-Rodriguez, C.,Levy, R.,Arndt, J.W.,Forsyth, C.M.,Razai, A.,Lou, J.,Geren, I.,Stevens, R.C.,Marks, J.D.
Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin.
Nat.Biotechnol., 25:107-116, 2007
PubMed: 17173035 (PDB entries with the same primary citation)
DOI: 10.1038/nbt1269
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.61 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.248142.3%6.1%2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution