2NXD
Structure of HIV-1 protease D25N complexed with rt-rh analogue peptide GLY-ALA-ASP-ILE-PHE*TYR-LEU-ASP-GLY-ALA
Summary for 2NXD
Entry DOI | 10.2210/pdb2nxd/pdb |
Related | 1KJG 2NXL 2NXM |
Descriptor | PROTEASE RETROPEPSIN, Analogue of RT-RH pol protease substrate peptide (3 entities in total) |
Functional Keywords | peptide design; molecular dynamics; hiv protease; substrate recognition; calorimetry, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate |
Biological source | HIV-1 M:B_ARV2/SF2 More |
Total number of polymer chains | 3 |
Total formula weight | 22670.72 |
Authors | Prabu-Jeyabalan, M.,Nalivaika, E.,Schiffer, C.A. (deposition date: 2006-11-17, release date: 2007-09-18, Last modification date: 2023-08-30) |
Primary citation | Altman, M.D.,Nalivaika, E.A.,Prabu-Jeyabalan, M.,Schiffer, C.A.,Tidor, B. Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV-1 protease Proteins, 70:678-694, 2007 Cited by PubMed: 17729291DOI: 10.1002/prot.21514 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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