2NV6

Mycobacterium tuberculosis InhA (S94A) bound with INH-NAD adduct

2NV6 の概要

• エントリーDOI: 10.2210/pdb2nv6/pdb
• 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH, ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE (3 entities in total)
• 機能のキーワード: inha, s94a, tuberculosis, isoniazid, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29146.08

構造登録者

Wang, F.,Sacchettini, J.C. (登録日: 2006-11-10, 公開日: 2006-11-21, 最終更新日: 2023-08-30)

• 主引用文献: Vilcheze, C.,Wang, F.,Arai, M.,Hazbon, M.H.,Colangeli, R.,Kremer, L.,Weisbrod, T.R.,Alland, D.,Sacchettini, J.C.,Jacobs Jr., W.R.; Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.; NAT.MED. (N.Y.), 12:1027-1029, 2006; PubMed: 16906155; DOI: 10.1038/nm1466

実験手法

X-RAY DIFFRACTION (1.9 Å)