2NS3

Solution structure of ribbon BuIA

Summary for 2NS3

Entry DOI	10.2210/pdb2ns3/pdb
Descriptor	Alpha-conotoxin BuIA (1 entity in total)
Functional Keywords	ribbon disulfide connectivity, toxin
Cellular location	Secreted: P69657
Total number of polymer chains	1
Total formula weight	1314.60
Authors	Jin, A.H.,Brandstaetter, H.,Nevin, S.T.,Tan, C.C.,Clark, R.J.,Adams, D.J.,Alewood, P.F.,Craik, D.J.,Daly, N.L. (deposition date: 2006-11-03, release date: 2007-09-25, Last modification date: 2024-10-16)
Primary citation	Jin, A.H.,Brandstaetter, H.,Nevin, S.T.,Tan, C.C.,Clark, R.J.,Adams, D.J.,Alewood, P.F.,Craik, D.J.,Daly, N.L. Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics Bmc Struct.Biol., 7:28-28, 2007 Cited by PubMed Abstract: Alpha-conotoxins have exciting therapeutic potential based on their high selectivity and affinity for nicotinic acetylcholine receptors. The spacing between the cysteine residues in alpha-conotoxins is variable, leading to the classification of sub-families. BuIA is the only alpha-conotoxin containing a 4/4 cysteine spacing and thus it is of significant interest to examine the structure of this conotoxin. PubMed: 17445276 DOI: 10.1186/1472-6807-7-28 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation