2NS3

Solution structure of ribbon BuIA

2NS3 の概要

• エントリーDOI: 10.2210/pdb2ns3/pdb
• 分子名称: Alpha-conotoxin BuIA (1 entity in total)
• 機能のキーワード: ribbon disulfide connectivity, toxin
• 細胞内の位置: Secreted: P69657
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 1314.60

構造登録者

Jin, A.H.,Brandstaetter, H.,Nevin, S.T.,Tan, C.C.,Clark, R.J.,Adams, D.J.,Alewood, P.F.,Craik, D.J.,Daly, N.L. (登録日: 2006-11-03, 公開日: 2007-09-25, 最終更新日: 2024-10-16)

主引用文献

Jin, A.H.,Brandstaetter, H.,Nevin, S.T.,Tan, C.C.,Clark, R.J.,Adams, D.J.,Alewood, P.F.,Craik, D.J.,Daly, N.L.
Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics
Bmc Struct.Biol., 7:28-28, 2007

PubMed Abstract: Alpha-conotoxins have exciting therapeutic potential based on their high selectivity and affinity for nicotinic acetylcholine receptors. The spacing between the cysteine residues in alpha-conotoxins is variable, leading to the classification of sub-families. BuIA is the only alpha-conotoxin containing a 4/4 cysteine spacing and thus it is of significant interest to examine the structure of this conotoxin.

PubMed: 17445276
DOI: 10.1186/1472-6807-7-28

実験手法

SOLUTION NMR