2NQ8

Malarial enoyl acyl ACP reductase bound with INH-NAD adduct

Summary for 2NQ8

Entry DOI	10.2210/pdb2nq8/pdb
Descriptor	Enoyl-acyl carrier reductase, ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE, ... (4 entities in total)
Functional Keywords	pfenr; inh; malaria, oxidoreductase
Biological source	Plasmodium falciparum (malaria parasite P. falciparum) More
Total number of polymer chains	4
Total formula weight	66685.53
Authors	Freundlich, J.S.,Yu, M.,Lucumi, E.,Kuo, M.,Tsai, H.C.,Valderramos, J.C.,Karagyozov, L.,Jacobs Jr., W.R.,Schiehser, G.A.,Fidock, D.A.,Jacobus, D.P.,Sacchettini, J.C. (deposition date: 2006-10-30, release date: 2007-07-17, Last modification date: 2023-08-30)
Primary citation	Freundlich, J.S.,Wang, F.,Tsai, H.C.,Kuo, M.,Shieh, H.M.,Anderson, J.W.,Nkrumah, L.J.,Valderramos, J.C.,Yu, M.,Kumar, T.R.,Valderramos, S.G.,Jacobs, W.R.,Schiehser, G.A.,Jacobus, D.P.,Fidock, D.A.,Sacchettini, J.C. X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy J.Biol.Chem., 282:25436-25444, 2007 Cited by PubMed: 17567585 DOI: 10.1074/jbc.M701813200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation