2NPL

NMR Structure of CARD d2 Domain

2NPL の概要

• エントリーDOI: 10.2210/pdb2npl/pdb
• 関連するPDBエントリー: 1RSF
• NMR情報: BMRB: 7291
• 分子名称: Coxsackievirus and Adenovirus Receptor (1 entity in total)
• 機能のキーワード: coxsakievirus and adenovirus receptor, cell adhesion
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Secreted: P78310
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10539.77

構造登録者

Jiang, S.,Caffrey, M. (登録日: 2006-10-27, 公開日: 2007-03-13, 最終更新日: 2024-10-30)

主引用文献

Jiang, S.,Caffrey, M.
Solution structure of the coxsackievirus and adenovirus receptor domain 2
Protein Sci., 16:539-542, 2007

PubMed Abstract: The coxsackievirus and adenovirus receptor (CAR) mediates entry of coxsackievirus and adenovirus. CAR possesses an extracellular region that is comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the present work, the solution structure of CAR-D2, consisting of residues 142-235 of human CAR, has been determined by NMR spectroscopy. CAR-D2 is shown to be a beta-sandwich motif comprised of two beta-sheets, which are stabilized by two disulfide bonds. The first beta-sheet is comprised of beta-strands A, B, and E, and the second beta-sheet is comprised of beta-strands C, F, and G. A relatively hydrophobic helix is found between beta-strands C and E, which replaces beta-strand D of the classical c-type immunoglobulin fold.

PubMed: 17322536
DOI: 10.1110/ps.062643507

実験手法

SOLUTION NMR