2NNP
Crystal structure analysis of HIV-1 protease mutant I84V with a inhibitor saquinavir
Summary for 2NNP
Entry DOI | 10.2210/pdb2nnp/pdb |
Related | 2NMW 2NMY 2NMZ 2NNK |
Related PRD ID | PRD_000454 |
Descriptor | PROTEASE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, ACETIC ACID, ... (6 entities in total) |
Functional Keywords | hiv-1 protease, mutant, i84v, dimer, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04587 |
Total number of polymer chains | 2 |
Total formula weight | 22524.50 |
Authors | Tie, Y.,Kovalevsky, A.Y.,Boross, P.,Wang, Y.F.,Ghosh, A.K.,Tozser, J.,Harrison, R.W.,Weber, I.T. (deposition date: 2006-10-24, release date: 2007-03-13, Last modification date: 2023-12-27) |
Primary citation | Tie, Y.,Kovalevsky, A.Y.,Boross, P.,Wang, Y.F.,Ghosh, A.K.,Tozser, J.,Harrison, R.W.,Weber, I.T. Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir. Proteins, 67:232-242, 2007 Cited by PubMed: 17243183DOI: 10.1002/prot.21304 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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