2NAF

Solution structure of peptidyl-tRNA hydrolase from Mycobacterium smegmatis

2NAF の概要

• エントリーDOI: 10.2210/pdb2naf/pdb
• 分子名称: Peptidyl-tRNA hydrolase (1 entity in total)
• 機能のキーワード: protein, hydrolase
• 由来する生物種: Mycobacterium smegmatis str. MC2 155
• 細胞内の位置: Cytoplasm : A0R3D3
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20306.32

構造登録者

Yadav, R.,Pathak, P.,Fatma, F.,Kabra, A.,Pulavarti, S.,Jain, A.,Kumar, A.,Shukla, V.,Arora, A. (登録日: 2015-12-23, 公開日: 2017-01-11, 最終更新日: 2024-05-15)

主引用文献

Kabra, A.,Fatma, F.,Shahid, S.,Pathak, P.P.,Yadav, R.,Pulavarti, S.V.,Tripathi, S.,Jain, A.,Arora, A.
Structural characterization of peptidyl-tRNA hydrolase from Mycobacterium smegmatis by NMR spectroscopy.
Biochim.Biophys.Acta, 1864:1304-1314, 2016

PubMed Abstract: Accumulation of toxic peptidyl-tRNAs in the bacterial cytoplasm is averted by the action of peptidyl-tRNA hydrolase (Pth), which cleaves peptidyl-tRNA into free tRNA and peptide. NMR studies are needed for a protein homolog with a complete crystal structure, for comparison with the NMR structure of Mycobacterium tuberculosis Pth.

PubMed: 27378575
DOI: 10.1016/j.bbapap.2016.06.013

実験手法

SOLUTION NMR