2NAA

NSD1-PHD_5-C5HCH tandem domain structure

Summary for 2NAA

• Entry DOI: 10.2210/pdb2naa/pdb
• Related: 2NAB
• NMR Information: BMRB: 25933
• Descriptor: Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, ZINC ION (2 entities in total)
• Functional Keywords: nsd1, phd5c5hch, phd finger, tandem, transcription
• Biological source: Mus musculus (mouse)
• Cellular location: Nucleus : O88491
• Total number of polymer chains: 1
• Total formula weight: 10741.67

Authors

Berardi, A.,Quilici, G.,Spiliotopoulos, D.,Musco, G. (deposition date: 2015-12-22, release date: 2016-03-09, Last modification date: 2023-06-14)

• Primary citation: Berardi, A.,Quilici, G.,Spiliotopoulos, D.,Corral-Rodriguez, M.A.,Martin-Garcia, F.,Degano, M.,Tonon, G.,Ghitti, M.,Musco, G.; Structural basis for PHDVC5HCHNSD1-C2HRNizp1 interaction: implications for Sotos syndrome.; Nucleic Acids Res., 44:3448-3463, 2016; PubMed: 26896805; DOI: 10.1093/nar/gkw103

Experimental method

SOLUTION NMR