2N9D

Structure analysis of the Tom1 GAT domain reveals distinct ligand-specific conformational states

2N9D の概要

• エントリーDOI: 10.2210/pdb2n9d/pdb
• NMR情報: BMRB: 26574
• 分子名称: Target of Myb protein 1 (1 entity in total)
• 機能のキーワード: transport protein, tom1, early endosomes, alternative escrt-0 member, cargo
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : O60784
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11501.09

構造登録者

Xiao, S.,Jeffrey, E.F.,Geoffrey, A.S.,Capelluto, D.G.S. (登録日: 2015-11-15, 公開日: 2016-09-21, 最終更新日: 2024-05-01)

主引用文献

Xiao, S.,Ellena, J.F.,Armstrong, G.S.,Capelluto, D.G.
Structure of the GAT domain of the endosomal adapter protein Tom1.
Data Brief, 7:344-348, 2016

PubMed Abstract: Cellular homeostasis requires correct delivery of cell-surface receptor proteins (cargo) to their target subcellular compartments. The adapter proteins Tom1 and Tollip are involved in sorting of ubiquitinated cargo in endosomal compartments. Recruitment of Tom1 to the endosomal compartments is mediated by its GAT domain's association to Tollip's Tom1-binding domain (TBD). In this data article, we report the solution NMR-derived structure of the Tom1 GAT domain. The estimated protein structure exhibits a bundle of three helical elements. We compare the Tom1 GAT structure with those structures corresponding to the Tollip TBD- and ubiquitin-bound states.

PubMed: 26977434
DOI: 10.1016/j.dib.2016.02.042

実験手法

SOLUTION NMR