2N7N

NMR structure of Peptide PG-989 in DPC micelles

Summary for 2N7N

• Entry DOI: 10.2210/pdb2n7n/pdb
• Related: 2N7O
• NMR Information: BMRB: 25813
• Descriptor: Peptide PG-989 (1 entity in total)
• Functional Keywords: de novo protein
• Biological source: synthetic construct
• Total number of polymer chains: 1
• Total formula weight: 1084.29

Authors

Carotenuto, A.,Merlino, F.,Chai, M.,Brancaccio, D.,Yousif, A.,Novellino, E.,Hruby, V.,Grieco, P. (deposition date: 2015-09-16, release date: 2015-12-16, Last modification date: 2024-10-30)

Primary citation

Carotenuto, A.,Merlino, F.,Cai, M.,Brancaccio, D.,Yousif, A.M.,Novellino, E.,Hruby, V.J.,Grieco, P.
Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor.
J.Med.Chem., 58:9773-9778, 2015

PubMed Abstract: The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated pathophysiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective ligands. Here, we report the design, synthesis, biological activity, conformational analysis, and docking with receptors of two potent and selective agonists at the human MC3 receptor.

PubMed: 26599352
DOI: 10.1021/acs.jmedchem.5b01285

Experimental method

SOLUTION NMR