2N65

Disulphide linked homodimer of designed antimicrobial peptide VG16KRKP

2N65 の概要

• エントリーDOI: 10.2210/pdb2n65/pdb
• 関連するPDBエントリー: 2N63
• NMR情報: BMRB: 25751
• 分子名称: antimicrobial peptide VG16KRKP (1 entity in total)
• 機能のキーワード: disulphide linked vg16krkp homodimer, designed antimicrobial peptide, de novo protein, antimicrobial protein
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 3530.31

構造登録者

Datta, A.,Bhunia, A. (登録日: 2015-08-12, 公開日: 2016-03-23, 最終更新日: 2024-10-30)

主引用文献

Datta, A.,Kundu, P.,Bhunia, A.
Designing potent antimicrobial peptides by disulphide linked dimerization and N-terminal lipidation to increase antimicrobial activity and membrane perturbation: Structural insights into lipopolysaccharide binding.
J Colloid Interface Sci, 461:335-345, 2016

PubMed Abstract: The remarkable rise in multi-drug resistant Gram-negative bacterial pathogens is a major concern to the well being of humans as well as susceptible plants. In recent years, diseases associated with inflammation and septicemia have already become a global health issue. Therefore, there is a rising demand for the development of novel "super" antibiotics. In this context, antimicrobial peptides offer an attractive, alternate therapeutic solution to conventional antibiotics.

PubMed: 26407061
DOI: 10.1016/j.jcis.2015.09.036

実験手法

SOLUTION NMR