2N63

Structure of C4VG16KRKP

Summary for 2N63

Entry DOI	10.2210/pdb2n63/pdb
Related	2N65
NMR Information	BMRB: 25749
Descriptor	antimicrobial peptide C4VG16KRKP, PENTANOIC ACID (2 entities in total)
Functional Keywords	lipidated peptide, designed antimicrobial peptide, de novo protein, antimicrobial protein
Biological source	synthetic construct
Total number of polymer chains	1
Total formula weight	1867.29
Authors	Bhunia, A.,Datta, A. (deposition date: 2015-08-11, release date: 2016-03-23, Last modification date: 2024-10-16)
Primary citation	Datta, A.,Kundu, P.,Bhunia, A. Designing potent antimicrobial peptides by disulphide linked dimerization and N-terminal lipidation to increase antimicrobial activity and membrane perturbation: Structural insights into lipopolysaccharide binding. J Colloid Interface Sci, 461:335-345, 2016 Cited by PubMed Abstract: The remarkable rise in multi-drug resistant Gram-negative bacterial pathogens is a major concern to the well being of humans as well as susceptible plants. In recent years, diseases associated with inflammation and septicemia have already become a global health issue. Therefore, there is a rising demand for the development of novel "super" antibiotics. In this context, antimicrobial peptides offer an attractive, alternate therapeutic solution to conventional antibiotics. PubMed: 26407061 DOI: 10.1016/j.jcis.2015.09.036 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation