2N5S

Spatial structure of EGFR transmembrane and juxtamembrane domains in DPC micelles

2N5S の概要

• エントリーDOI: 10.2210/pdb2n5s/pdb
• NMR情報: BMRB: 25729
• 分子名称: Epidermal growth factor receptor (1 entity in total)
• 機能のキーワード: transmembrane, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 5979.34

構造登録者

Mineev, K.,Bocharov, E.,Bocharova, O.,Arseniev, A. (登録日: 2015-07-27, 公開日: 2015-10-14, 最終更新日: 2024-05-15)

主引用文献

Mineev, K.S.,Panova, S.V.,Bocharova, O.V.,Bocharov, E.V.,Arseniev, A.S.
The Membrane Mimetic Affects the Spatial Structure and Mobility of EGFR Transmembrane and Juxtamembrane Domains.
Biochemistry, 54:6295-6298, 2015

PubMed Abstract: The epidermal growth factor receptor (EGFR) is one of the most extensively studied receptor tyrosine kinases, as it is involved in a wide range of cellular processes and severe diseases. Recent works reveal that the single-helix transmembrane domains and cytoplasmic juxtamembrane regions play an important role in the receptor activation process. Here we present the results of our investigation of the spatial structure and mobility of the EGFR transmembrane domain and juxtamembrane regions in various membranelike environments, which shed light on the effects of the membrane physical properties and composition on the behavior of the juxtamembrane domain.

PubMed: 26440883
DOI: 10.1021/acs.biochem.5b00851

実験手法

SOLUTION NMR