2MZW
Staphylococcus aureus FusB:EF-GC3 complex
Summary for 2MZW
| Entry DOI | 10.2210/pdb2mzw/pdb |
| Related | 2XEX 4ADN |
| NMR Information | BMRB: 25504 |
| Descriptor | Elongation factor G, Far1, ZINC ION (3 entities in total) |
| Functional Keywords | antibiotic resistance, metal binding protein, translation-antibiotic resistance complex, translation/antibiotic resistance |
| Biological source | Staphylococcus aureus More |
| Cellular location | Cytoplasm : W8UT26 |
| Total number of polymer chains | 2 |
| Total formula weight | 60891.58 |
| Authors | Tomlinson, J.H.,Thompson, G.S.,Kalverda, A.P.,Zhuravleva, A.,O'Neill, A. (deposition date: 2015-02-25, release date: 2016-01-27, Last modification date: 2024-05-15) |
| Primary citation | Tomlinson, J.H.,Thompson, G.S.,Kalverda, A.P.,Zhuravleva, A.,O'Neill, A.J. A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance. Sci Rep, 6:19524-19524, 2016 Cited by PubMed Abstract: Antibiotic resistance in clinically important bacteria can be mediated by proteins that physically associate with the drug target and act to protect it from the inhibitory effects of an antibiotic. We present here the first detailed structural characterization of such a target protection mechanism mediated through a protein-protein interaction, revealing the architecture of the complex formed between the FusB fusidic acid resistance protein and the drug target (EF-G) it acts to protect. Binding of FusB to EF-G induces conformational and dynamic changes in the latter, shedding light on the molecular mechanism of fusidic acid resistance. PubMed: 26781961DOI: 10.1038/srep19524 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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