2MZ7

Structure of Tau(267-312) bound to Microtubules

2MZ7 の概要

• エントリーDOI: 10.2210/pdb2mz7/pdb
• 関連するPDBエントリー: 2MNK 2MNL 2MNM 2MNN 2MNO 2MNP
• NMR情報: BMRB: 25475
• 分子名称: Microtubule-associated protein tau (1 entity in total)
• 機能のキーワード: tau, microtubule, dynamics, protein binding
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytosol : P10636
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4892.68

構造登録者

Kadavath, H.,Jaremko, M.,Jaremko, L.,Zweckstetter, M. (登録日: 2015-02-06, 公開日: 2015-07-08, 最終更新日: 2024-05-15)

主引用文献

Kadavath, H.,Jaremko, M.,Jaremko, M.,Biernat, J.,Mandelkow, E.,Zweckstetter, M.
Folding of the Tau Protein on Microtubules.
Angew.Chem.Int.Ed.Engl., 54:10347-10351, 2015

PubMed Abstract: Microtubules are regulated by microtubule-associated proteins. However, little is known about the structure of microtubule-associated proteins in complex with microtubules. Herein we show that the microtubule-associated protein Tau, which is intrinsically disordered in solution, locally folds into a stable structure upon binding to microtubules. While Tau is highly flexible in solution and adopts a β-sheet structure in amyloid fibrils, in complex with microtubules the conserved hexapeptides at the beginning of the Tau repeats two and three convert into a hairpin conformation. Thus, binding to microtubules stabilizes a unique conformation in Tau.

PubMed: 26094605
DOI: 10.1002/anie.201501714

実験手法

SOLUTION NMR