2MXQ

The solution structure of DEFA1, a highly potent antimicrobial peptide from the horse

2MXQ の概要

• エントリーDOI: 10.2210/pdb2mxq/pdb
• NMR情報: BMRB: 25424
• 分子名称: Paneth cell-specific alpha-defensin 1 (1 entity in total)
• 機能のキーワード: antimicrobial protein
• 由来する生物種: Equus caballus (domestic horse,equine)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4086.81

構造登録者

Jung, S.,Michalek, M.,Shomali, M.,Soennichsen, F.D. (登録日: 2015-01-12, 公開日: 2015-04-22, 最終更新日: 2024-11-20)

主引用文献

Michalek, M.,Jung, S.,Shomali, M.R.,Cauchard, S.,Sonnichsen, F.D.,Grotzinger, J.
Solution structure and functional studies of the highly potent equine antimicrobial peptide DEFA1.
Biochem.Biophys.Res.Commun., 459:668-672, 2015

PubMed Abstract: Defensins are small effector molecules of the innate immune system that are present in almost all organisms including plants and animals. These peptides possess antimicrobial activity against a broad range of microbes including bacteria, fungi and viruses and act as endogenous antibiotics. α-Defensins are a subfamily of the defensin family and their expression is limited to specific tissues. Equine DEFA1 is an enteric α-defensin exclusively secreted by Paneth cells and shows an activity against a broad spectrum of microbes, including typical pathogens of the horse such as Rhodococcus equi, various streptococci strains, Salmonella choleraesuis, and Pasteurella multocida. Here, we report the three-dimensional structure of DEFA1 solved by NMR-spectroscopy and demonstrate its specific function of aggregating various phospholipids.

PubMed: 25769951
DOI: 10.1016/j.bbrc.2015.02.168

実験手法

SOLUTION NMR