2MUJ

Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

Summary for 2MUJ

• Entry DOI: 10.2210/pdb2muj/pdb
• NMR Information: BMRB: 25215
• Descriptor: Serine-repeat antigen protein (1 entity in total)
• Functional Keywords: sera, peptide analogue, membrane protein
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 1
• Total formula weight: 2531.86

Authors

Cubillos, M.,Alba, M.,Bermudez, A.,Trujillo, M.,Patarroyo, M.E. (deposition date: 2014-09-10, release date: 2015-02-11, Last modification date: 2024-05-15)

Primary citation

Cubillos, M.,Alba, M.P.,Bermudez, A.,Trujillo, M.,Patarroyo, M.E.
Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria.
Biochimie, 85:651-657, 2003

PubMed Abstract: Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides' secondary structure and their function as immunogen against malaria.

PubMed: 14505820

Experimental method

SOLUTION NMR