2MUJ

Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

2MUJ の概要

• エントリーDOI: 10.2210/pdb2muj/pdb
• NMR情報: BMRB: 25215
• 分子名称: Serine-repeat antigen protein (1 entity in total)
• 機能のキーワード: sera, peptide analogue, membrane protein
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2531.86

構造登録者

Cubillos, M.,Alba, M.,Bermudez, A.,Trujillo, M.,Patarroyo, M.E. (登録日: 2014-09-10, 公開日: 2015-02-11, 最終更新日: 2024-05-15)

主引用文献

Cubillos, M.,Alba, M.P.,Bermudez, A.,Trujillo, M.,Patarroyo, M.E.
Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria.
Biochimie, 85:651-657, 2003

PubMed Abstract: Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides' secondary structure and their function as immunogen against malaria.

PubMed: 14505820

実験手法

SOLUTION NMR