2MTI

NMR structure of the lymphocyte receptor NKR-P1A

2MTI の概要

• エントリーDOI: 10.2210/pdb2mti/pdb
• NMR情報: BMRB: 19282
• 分子名称: Killer cell lectin-like receptor subfamily B member 1A (1 entity in total)
• 機能のキーワード: c-type lectin-like domain, nk cells, nk receptor, nkr-p1a, immune system
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16008.77

構造登録者

Chmelik, J.,Rozbesky, D.,Pospisilova, E.,Adamek, D.,Novak, P. (登録日: 2014-08-19, 公開日: 2015-11-11, 最終更新日: 2024-10-16)

主引用文献

Rozbesky, D.,Adamek, D.,Pospisilova, E.,Novak, P.,Chmelik, J.
Solution structure of the lymphocyte receptor Nkrp1a reveals a distinct conformation of the long loop region as compared to in the crystal structure.
Proteins, 84:1304-1311, 2016

PubMed Abstract: Mouse Nkrp1a receptor is a C-type lectin-like receptor expressed on the surface of natural killer cells that play an important role against virally infected and tumor cells. The recently solved crystal structure of Nkrp1a raises questions about a long loop region which was uniquely extended from the central region in the crystal. To understand the functional significance of the loop, the solution structure of Nkrp1a using nuclear magnetic resonance (NMR) spectroscopy was determined. A notable difference between the crystal and NMR structure of Nkrp1a appears in the conformation of the long loop region. While the extended loop points away from the central core and mediates formation of a domain swapped dimer in the crystal, the solution structure is monomeric with the loop tightly anchored to the central region. The findings described the first solution structure in the Nkrp1 family and revealed intriguing similarities and differences to the crystal structure. Proteins 2016; 84:1304-1311. © 2016 Wiley Periodicals, Inc.

PubMed: 27238500
DOI: 10.1002/prot.25078

実験手法

SOLUTION NMR