2MSP

MAJOR SPERM PROTEIN, BETA ISOFORM, ENGINEERED C59S/T90C MUTANT, PUTATIVE SUBFILAMENT STRUCTURE, PH 8.5

2MSP の概要

• エントリーDOI: 10.2210/pdb2msp/pdb
• 分子名称: MAJOR SPERM PROTEIN (1 entity in total)
• 機能のキーワード: cytoskeletal protein, nematode sperm cell motility protein, filamentous protein structure, cell motility protein
• 由来する生物種: Ascaris suum (pig roundworm)
• 細胞内の位置: Cell projection, pseudopodium: P27440
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 112967.01

構造登録者

Bullock, T.L.,Mccoy, A.J.,Stewart, M. (登録日: 1997-12-19, 公開日: 1998-04-15, 最終更新日: 2024-05-22)

主引用文献

Bullock, T.L.,McCoy, A.J.,Kent, H.M.,Roberts, T.M.,Stewart, M.
Structural basis for amoeboid motility in nematode sperm.
Nat.Struct.Biol., 5:184-189, 1998

PubMed Abstract: Cell locomotion in amoeboid nematode sperm is generated by the vectorial assembly and bundling of filaments of the major sperm protein (MSP). MSP filaments are constructed from two helical subfilaments and here we describe the structure of putative MSP subfilament helices determined by X-ray crystallography at 3.3 A resolution. In addition to establishing the interfaces involved in polymerization, this structural model shows that the MSP helices are constructed from dimers and have no overall polarity, suggesting that it is unlikely that molecular motors play a direct role in the generation of protrusive force in these amoeboid cells.

PubMed: 9501910
DOI: 10.1038/nsb0398-184

実験手法

X-RAY DIFFRACTION (3.3 Å)