2MQ2

Cysteine Deleted Protegrin-1 (CDP-1): Anti-bacterial Activity, Outer-Membrane Disruption and Selectivity

2MQ2 の概要

• エントリーDOI: 10.2210/pdb2mq2/pdb
• 関連するPDBエントリー: 2MQ4 2MQ5
• NMR情報: BMRB: 25009
• 分子名称: CDP-1 peptide, Cysteine Deleted Protegrin-1 (1 entity in total)
• 機能のキーワード: beta hairpin, antimicrobial protein
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 1754.10

構造登録者

Mohanram, H.,Bhattacharjya, S. (登録日: 2014-06-11, 公開日: 2014-07-30, 最終更新日: 2024-05-15)

主引用文献

Mohanram, H.,Bhattacharjya, S.
Cysteine deleted protegrin-1 (CDP-1): anti-bacterial activity, outer-membrane disruption and selectivity.
Biochim.Biophys.Acta, 1840:3006-3016, 2014

PubMed Abstract: Protegin-1 (PG-1: RGGRLCYCRRRFCVCVGR-amide) assumes a rigid β-hairpin like structure that is stabilized by two disulfide bridges between Cys6-Cys15 and Cys8-Cys13. Previous studies, employing linear analogs of PG-1, with Cys to Ala mutations or modified Cys, have demonstrated that the disulfide bridges are critical for the broad spectrum and salt resistant antimicrobial activity of PG-1.

PubMed: 24997421
DOI: 10.1016/j.bbagen.2014.06.018

実験手法

SOLUTION NMR