2MNQ

1H, 13C, and 15N Chemical Shift Assignments for Thymosin alpha 1

2MNQ の概要

• エントリーDOI: 10.2210/pdb2mnq/pdb
• NMR情報: BMRB: 19901
• 分子名称: THYMOSIN ALPHA-1 (1 entity in total)
• 機能のキーワード: protein binding, hormone peptide, membrane interaction
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P06454
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3096.31

構造登録者

Nepravishta, R.,Mandaliti, W.,Eliseo, T.,Sinibaldi Vallebona, P.,Pica, F.,Garaci, E.,Paci, M. (登録日: 2014-04-09, 公開日: 2015-03-04, 最終更新日: 2024-10-16)

主引用文献

Nepravishta, R.,Mandaliti, W.,Eliseo, T.,Sinibaldi Vallebona, P.,Pica, F.,Garaci, E.,Paci, M.
Thymosin alpha 1 inserts N terminus into model membranes assuming a helical conformation.
Expert Opin Biol Ther, 15 Suppl 1:71-81, 2015

PubMed Abstract: Thymosin α1 (Tα1) is a peptide hormone whose therapeutic application has been approved in several diseases, but the description of a precise receptor for its therapeutic action still remains elusive and some knowledge of the mechanism of interaction with the cell membrane still needs to be clarified. This work is aimed at studying the folding and interaction of Tα1, which is completely unstructured in water solution, with model membranes.

PubMed: 25642593
DOI: 10.1517/14712598.2015.1009034

実験手法

SOLUTION NMR