2MK9

Spatial structure of the dimeric transmembrane domain of Toll-like receptor 3

2MK9 の概要

• エントリーDOI: 10.2210/pdb2mk9/pdb
• 関連するPDBエントリー: 2MKA
• NMR情報: BMRB: 19764
• 分子名称: Toll-like receptor 3 (1 entity in total)
• 機能のキーワード: transmembrane domain, dimer, immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass type I membrane protein: O15455
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 8179.89

構造登録者

Mineev, K.S.,Goncharuk, S.A.,Arseniev, A.S. (登録日: 2014-02-04, 公開日: 2014-09-17, 最終更新日: 2024-05-15)

主引用文献

Mineev, K.S.,Goncharuk, S.A.,Arseniev, A.S.
Toll-like receptor 3 transmembrane domain is able to perform various homotypic interactions: An NMR structural study.
Febs Lett., 588:3802-3807, 2014

PubMed Abstract: Toll-like receptors (TLRs) take part in both the innate and adaptive immune systems. The role of the transmembrane domain in TLR signaling is still elusive, while its importance for the TLR activation was clearly demonstrated. In the present study the ability of the TLR3 transmembrane domain to form dimers and trimers in detergent micelles was shown by solution NMR spectroscopy. Spatial structures and free energy magnitudes were determined for the TLR3 transmembrane domain in dimeric and trimeric states, and two possible surfaces that may be used for the helix-helix interaction by the full-length TLR3 were revealed.

PubMed: 25217833
DOI: 10.1016/j.febslet.2014.08.031

実験手法

SOLUTION NMR