2MGP
Structure of Plasmodium Yoelii Merozoite Surface Protein 1 - C-terminal Domain
Summary for 2MGP
| Entry DOI | 10.2210/pdb2mgp/pdb |
| Related | 2MGR |
| NMR Information | BMRB: 19233 |
| Descriptor | Merozoite surface protein 1 (1 entity in total) |
| Functional Keywords | membrane protein |
| Biological source | Plasmodium yoelii yoelii |
| Cellular location | Cell membrane; Lipid-anchor, GPI-anchor (By similarity): P13828 |
| Total number of polymer chains | 1 |
| Total formula weight | 10729.72 |
| Authors | Curd, R.D.,Birdsall, B.,Kadekoppala, M.,Ogun, S.,Kelly, G.,Holder, A.A. (deposition date: 2013-11-03, release date: 2014-02-12, Last modification date: 2024-11-13) |
| Primary citation | Curd, R.D.,Birdsall, B.,Kadekoppala, M.,Ogun, S.A.,Kelly, G.,Holder, A.A. The structure of Plasmodium yoelii merozoite surface protein 119, antibody specificity and implications for malaria vaccine design OPEN BIOLOGY, 4:130091-130091, 2014 Cited by PubMed Abstract: Merozoite surface protein 1 (MSP1) has been identified as a target antigen for protective immune responses against asexual blood stage malaria, but effective vaccines based on MSP1 have not been developed so far. We have modified the sequence of Plasmodium yoelii MSP119 (the C-terminal region of the molecule) and examined the ability of the variant proteins to bind protective monoclonal antibodies and to induce protection by immunization. In parallel, we examined the structure of the protein and the consequences of the amino acid changes. Naturally occurring sequence polymorphisms reduced the binding of individual protective antibodies, indicating that they contribute to immune evasion, but immunization with these variant proteins still provided protective immunity. One variant that resulted in the localized distortion of a loop close to the N-terminus of MSP119 almost completely ablated protection by immunization, indicating the importance of this region of MSP119 as a target for protective immunity and in vaccine development. PubMed: 24403012DOI: 10.1098/rsob.130091 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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