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2MGN

Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3

Summary for 2MGN
Entry DOI10.2210/pdb2mgn/pdb
NMR InformationBMRB: 19594
Descriptor5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*G)-3', N2,N9-bis(1-methylquinolin-3-yl)-1,10-phenanthroline-2,9-dicarboxamide (2 entities in total)
Functional Keywordsligand, c-myc promoter, dna
Total number of polymer chains1
Total formula weight8242.54
Authors
Chung, W.J.,Heddi, B.,Hamon, F.,Teulade-Fichou, M.P.,Phan, A.T. (deposition date: 2013-11-01, release date: 2014-01-22, Last modification date: 2024-05-15)
Primary citationChung, W.J.,Heddi, B.,Hamon, F.,Teulade-Fichou, M.P.,Phan, A.T.
Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3.
Angew.Chem.Int.Ed.Engl., 53:999-1002, 2014
Cited by
PubMed Abstract: Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural information revealed that Phen-DC3 interacts with the quadruplex through extensive π-stacking with guanine bases of the top G-tetrad. On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation.
PubMed: 24356977
DOI: 10.1002/anie.201308063
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

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數據於2025-07-09公開中

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