2MGN

Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3

Summary for 2MGN

• Entry DOI: 10.2210/pdb2mgn/pdb
• NMR Information: BMRB: 19594
• Descriptor: 5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*G)-3', N2,N9-bis(1-methylquinolin-3-yl)-1,10-phenanthroline-2,9-dicarboxamide (2 entities in total)
• Functional Keywords: ligand, c-myc promoter, dna
• Total number of polymer chains: 1
• Total formula weight: 8242.54

Authors

Chung, W.J.,Heddi, B.,Hamon, F.,Teulade-Fichou, M.P.,Phan, A.T. (deposition date: 2013-11-01, release date: 2014-01-22, Last modification date: 2024-05-15)

Primary citation

Chung, W.J.,Heddi, B.,Hamon, F.,Teulade-Fichou, M.P.,Phan, A.T.
Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3.
Angew.Chem.Int.Ed.Engl., 53:999-1002, 2014

PubMed Abstract: Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural information revealed that Phen-DC3 interacts with the quadruplex through extensive π-stacking with guanine bases of the top G-tetrad. On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation.

PubMed: 24356977
DOI: 10.1002/anie.201308063

Experimental method

SOLUTION NMR