2MC1

Solution structure of the Vav1 SH2 domain complexed with a Syk-derived singly phosphorylated peptide

2MC1 の概要

• エントリーDOI: 10.2210/pdb2mc1/pdb
• NMR情報: BMRB: 19423
• 分子名称: Proto-oncogene vav, Tyrosine-protein kinase SYK (2 entities in total)
• 機能のキーワード: syk kinase, tyrosine kinase, phosphorylated peptide, phosphotyrosine binding domain, b cell signaling protein, signaling protein-protein binding complex, signaling protein/protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane (Probable): P48025
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 13929.62

構造登録者

Chen, C.,Piraner, D.,Gorenstein, N.M.,Geahlen, R.L.,Post, C.B. (登録日: 2013-08-13, 公開日: 2013-08-28, 最終更新日: 2023-06-14)

• 主引用文献: Chen, C.H.,Piraner, D.,Gorenstein, N.M.,Geahlen, R.L.,Beth Post, C.; Differential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domain.; Biopolymers, 99:897-907, 2013; PubMed: 23955592; DOI: 10.1002/bip.22371

実験手法

SOLUTION NMR