2M6X

Structure of the p7 channel of Hepatitis C virus, genotype 5a

2M6X の概要

• エントリーDOI: 10.2210/pdb2m6x/pdb
• NMR情報: BMRB: 19162
• 分子名称: p7 (1 entity in total)
• 機能のキーワード: membrane protein, cation channel
• 由来する生物種: Hepatitis C virus (HCV)
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): O39928
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 40572.44

構造登録者

OuYang, B.,Chou, J.J. (登録日: 2013-04-12, 公開日: 2013-06-12, 最終更新日: 2024-05-01)

• 主引用文献: OuYang, B.,Xie, S.,Berardi, M.J.,Zhao, X.,Dev, J.,Yu, W.,Sun, B.,Chou, J.J.; Unusual architecture of the p7 channel from hepatitis C virus; Nature, 498:521-525, 2013; PubMed: 23739335; DOI: 10.1038/nature12283

実験手法

SOLUTION NMR