2M6V

Solution NMR structure of the d(GGGTTGGGTTTTGGGTGGG) quadruplex in sodium conditions

2M6V の概要

• エントリーDOI: 10.2210/pdb2m6v/pdb
• NMR情報: BMRB: 19158
• 分子名称: DNA (5'-D(*GP*GP*GP*TP*TP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*TP*GP*GP*G)-3') (1 entity in total)
• 機能のキーワード: g-quadruplex, folding topology, dna
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6034.86

構造登録者

Karsisiotis, A.I.,Webba da Silva, M. (登録日: 2013-04-10, 公開日: 2014-07-16, 最終更新日: 2024-05-15)

主引用文献

Dvorkin, S.A.,Karsisiotis, A.I.,Webba da Silva, M.
Encoding canonical DNA quadruplex structure.
Sci Adv, 4:eaat3007-eaat3007, 2018

PubMed Abstract: The main challenge in DNA quadruplex design is to encode a three-dimensional structure into the primary sequence, despite its multiple, repetitive guanine segments. We identify and detail structural elements describing all 14 feasible canonical quadruplex scaffolds and demonstrate their use in control of design. This work outlines a new roadmap for implementation of targeted design of quadruplexes for material, biotechnological, and therapeutic applications.

PubMed: 30182059
DOI: 10.1126/sciadv.aat3007

実験手法

SOLUTION NMR