2M0Y

Solution structure of the SH3 domain of DOCK180

2M0Y の概要

• エントリーDOI: 10.2210/pdb2m0y/pdb
• NMR情報: BMRB: 18832
• 分子名称: Dedicator of cytokinesis protein 1 (1 entity in total)
• 機能のキーワード: apoptosis
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Cytoplasm (By similarity): Q8BUR4
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8659.84

構造登録者

Liu, X.,Wen, W. (登録日: 2012-11-08, 公開日: 2012-12-19, 最終更新日: 2024-05-15)

主引用文献

Liu, X.,Li, F.,Pan, Z.,Wang, W.,Wen, W.
Solution structure of the SH3 domain of DOCK180.
Proteins, 81:906-910, 2013

PubMed Abstract: DOCK180 family proteins are Rho guanine nucleotide exchange factors. DOCK1-5 contains an N-terminal SH3 domain implicated in their autoinhibition. Release of the closed conformation requires the interaction between SH3 and engulfment and cell motility (ELMO). Here, we solved the solution structure of DOCK180 SH3 domain, which shares similar target binding features with the SH3 domain of DOCK2. The conserved N-terminal extension packs with the SH3 core domain and forms a new target binding site distinct from the canonical "PxxP" site. Our results demonstrate that the bidentate target binding mode of DOCK180 SH3 domain might be a general feature in all DOCK proteins.

PubMed: 23239367
DOI: 10.1002/prot.24236

実験手法

SOLUTION NMR