2M01

Solution structure of Kunitz-type neurotoxin LmKKT-1a from scorpion venom

2M01 の概要

• エントリーDOI: 10.2210/pdb2m01/pdb
• NMR情報: BMRB: 18789
• 分子名称: Protease inhibitor LmKTT-1a (1 entity in total)
• 機能のキーワード: scorpion potassium channel toxin, kunitz-type neurotoxin, toxin
• 由来する生物種: Lychas mucronatus (Chinese striped bark scorpion,Vietnamese brown scorpion)
• 細胞内の位置: Secreted (By similarity): P0DJ46
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6510.27

構造登録者

Luo, F.,Jiang, L.,Liu, M.,Chen, Z.,Wu, Y. (登録日: 2012-10-15, 公開日: 2013-11-13, 最終更新日: 2024-10-30)

主引用文献

Chen, Z.,Luo, F.,Feng, J.,Yang, W.,Zeng, D.,Zhao, R.,Cao, Z.,Liu, M.,Li, W.,Jiang, L.,Wu, Y.
Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins.
Plos One, 8:e60201-e60201, 2013

PubMed Abstract: Recently, a new subfamily of long-chain toxins with a Kunitz-type fold was found in scorpion venom glands. Functionally, these toxins inhibit protease activity and block potassium channels. However, the genomic organization and three-dimensional (3-D) structure of this kind of scorpion toxin has not been reported.

PubMed: 23573241
DOI: 10.1371/journal.pone.0060201

実験手法

SOLUTION NMR