2LYW

Intermolecular interactions between neurotensin and the third extracellular loop of human neurotensin 1 receptor

2LYW の概要

• エントリーDOI: 10.2210/pdb2lyw/pdb
• 分子名称: Neurotensin receptor type 1, Neurotensin (2 entities in total)
• 機能のキーワード: interaction ligand/receptor, nts1, signaling protein-neuropeptide complex, signaling protein/neuropeptide
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 4856.52

構造登録者

Monti, J.,Da Costa, G. (登録日: 2012-09-20, 公開日: 2012-12-12, 最終更新日: 2024-11-06)

主引用文献

Da Costa, G.,Bondon, A.,Coutant, J.,Curmi, P.,Monti, J.P.
Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor.
J.Biomol.Struct.Dyn., 31:1381-1392, 2013

PubMed Abstract: Neurotensin (NT) is a tridecapeptide hormone in the periphery and neurotransmitter in the brain that principally activates three receptor subtypes, named NTS1, NTS2, and NTS3. Since little is known about its structure in the presence of its principal receptor NTS1, we determined it using the key domain of the receptor, i.e. the third extracellular loop. We conclude the following: (i) for the receptor fragment, NT binding modifies its central part, underlying the great flexibility and adaptability of this region; (ii) for bound NT, the extended conformation of its C-terminus is confirmed for the first time in experimental conditions and in the presence of a part of the receptor; and (iii) despite some substitutions, the human receptor residues that are involved in the interaction with NT could be similar to those of the rat receptor which play an important role in NT binding.

PubMed: 23140271
DOI: 10.1080/07391102.2012.736776

実験手法

SOLUTION NMR