2LY4

HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail

2LY4 の概要

• エントリーDOI: 10.2210/pdb2ly4/pdb
• NMR情報: BMRB: 18709
• 分子名称: High mobility group protein B1, Cellular tumor antigen p53 (2 entities in total)
• 機能のキーワード: hmg, p53, tad, nuclear protein-antitumour protein complex, nuclear protein/antitumour protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P09429; Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 19686.19

構造登録者

Rowell, J.P.,Simpson, K.L.,Stott, K.,Watson, M.,Thomas, J.O. (登録日: 2012-09-12, 公開日: 2012-10-31, 最終更新日: 2012-12-26)

• 主引用文献: Rowell, J.P.,Simpson, K.L.,Stott, K.,Watson, M.,Thomas, J.O.; HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail.; Structure, 20:2014-2024, 2012; PubMed: 23063560; DOI: 10.1016/j.str.2012.09.004

実験手法

SOLUTION NMR