2LVG

NMR structure of HCV Non-structural protein AB, NS4B(1-40)

2LVG の概要

• エントリーDOI: 10.2210/pdb2lvg/pdb
• 関連するPDBエントリー: 2jxf
• NMR情報: BMRB: 18568
• 分子名称: Non-structural protein 4B (1 entity in total)
• 機能のキーワード: membrane protein
• 由来する生物種: Hepatitis C virus JFH-1 (HCV)
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : Q99IB8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4385.05

構造登録者

Montserret, R.,Penin, F. (登録日: 2012-07-05, 公開日: 2013-06-19, 最終更新日: 2023-06-14)

• 主引用文献: Gouttenoire, J.,Montserret, R.,Paul, D.,Castillo, R.,Meister, S.,Bartenschlager, R.,Penin, F.,Moradpour, D.; Aminoterminal Amphipathic alpha-Helix AH1 of Hepatitis C Virus Nonstructural Protein 4B Possesses a Dual Role in RNA Replication and Virus Production.; Plos Pathog., 10:e1004501-e1004501, 2014; PubMed: 25392992; DOI: 10.1371/journal.ppat.1004501

実験手法

SOLUTION NMR